OPTIMUM study protocol: an adaptive randomised controlled trial of a mixed whole-cell/acellular pertussis vaccine schedule
… the primary endpoint if there is evidence of sensitisation to a food on skin prick test, and
either: … We seek their wisdom in our work to improve the health and development of all. We …
either: … We seek their wisdom in our work to improve the health and development of all. We …
[HTML][HTML] Prevalidation of the cAMP-PTx reporter assay for quantitative assessment of pertussis toxin activity
L de Brouwer, D David, ME Ballestas, A Sloots… - Vaccine, 2022 - Elsevier
… and global replacement of the histamine sensitization test. … form the second generation of
pertussis vaccines to protect … The HIST is based on increased sensitivity to histamine upon …
pertussis vaccines to protect … The HIST is based on increased sensitivity to histamine upon …
[HTML][HTML] … involved in pertussis toxin-mediated cell clustering and its implications in the in vitro quality control of diphtheria tetanus and whole cell pertussis vaccines
HP da Silva Zamith, RO Godinho, VL da Costa Junior… - Toxicology in Vitro, 2021 - Elsevier
… 9 g/L) PTx did not correlate with any increase in cAMP levels. In contrast, in cells treated with
… to the murine histamine sensitization test (HIST) for acellular pertussis vaccines: state of the …
… to the murine histamine sensitization test (HIST) for acellular pertussis vaccines: state of the …
The nearest neighbor nuclei method to objectify analysis of pertussis toxin-induced clustering
ME Hoonakker, E Remarque, J Veth, A Sloots… - ALTEX-Alternatives to …, 2022 - altex.org
… The in vivo histamine sensitization test (HIST) has historically … In commercial acellular pertussis
vaccines spiked with PTx, … adjacent nuclei might improve the sensitivity of the test further (…
vaccines spiked with PTx, … adjacent nuclei might improve the sensitivity of the test further (…
In Vivo Models and In Vitro Assays for the Assessment of Pertussis Toxin Activity
ME Hoonakker - Toxins, 2021 - mdpi.com
… area of use is testing of acellular pertussis vaccines for the … vial for the in vivo histamine
sensitization test and the in vitro CHO (… between the increased sensitivity to histamine in mice and …
sensitization test and the in vitro CHO (… between the increased sensitivity to histamine in mice and …
iGIST—A Kinetic Bioassay for Pertussis Toxin Based on Its Effect on Inhibitory GPCR Signaling
VM Paramonov, C Sahlgren, A Rivero-Müller… - ACS …, 2020 - ACS Publications
… figures, of 0.8 and 0.4 histamine sensitization units/mL (HSU/… safety and efficacy of acellular
pertussis vaccines”, these values … , which improves specificity and increases the sensitivity of …
pertussis vaccines”, these values … , which improves specificity and increases the sensitivity of …
The history of pertussis toxin
C Locht, R Antoine - Toxins, 2021 - mdpi.com
… in acellular pertussis vaccines and possibly new-generation … to be significantly increased in
pertussis patients compared to … pertussis developed a high degree of sensitivity to histamine …
pertussis patients compared to … pertussis developed a high degree of sensitivity to histamine …
A genetic locus complements resistance to Bordetella pertussis-induced histamine sensitization
… (SNP) based association testing across laboratory and wild-… , enhancer of Bordetella pertussis
induced histamine sensitization. … to HA sensitization, PTX-treated mice exhibit increased …
induced histamine sensitization. … to HA sensitization, PTX-treated mice exhibit increased …
[HTML][HTML] Protocol: OPTIMUM study protocol: an adaptive randomised controlled trial of a mixed whole-cell/acellular pertussis vaccine schedule
… the primary endpoint if there is evidence of sensitisation to a food on skin prick test, and
either: … We seek their wisdom in our work to improve the health and development of all. We …
either: … We seek their wisdom in our work to improve the health and development of all. We …
[PDF][PDF] In Vivo Models and
ME Hoonakker - HIST, 2021 - academia.edu
… area of use is testing of acellular pertussis vaccines for the … The histamine sensitization test
is based on the sensitizing … between the increased sensitivity to histamine in mice and the …
is based on the sensitizing … between the increased sensitivity to histamine in mice and the …